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KMID : 0811820120160020138
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Journal of Korean Society of Pediatric Nephrology
2012 Volume.16 No. 2 p.138 ~ p.141
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Kikuchi-Fujimoto Disease, A Possible Complication of Rituximab Treatment
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Lee Ji-Won
Chang Hye-Jin
Lee Sang-Taek
Kang Hee-Gyung
Ha Il-Soo
Cheong Hae-Il
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Abstract
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Rituximab, a chimeric anti-CD20 IgG1 monoclonal antibody, has been used as a rescue therapy for steroid-dependent or refractory nephrotic syndrome. However, the adverse effects of rituximab are yet to be investigated. We report a case of a 9-year-old boy with steroid-dependent nephrotic syndrome who developed Kikuchi-Fujimoto disease after several cycles of rituximab therapy. Kikuchi-Fujimoto disease is a benign, self-limited necrotizing histiocytic lymphadenitis of unknown etiology. In the present case, Kikuchi-Fujimoto disease developed when the peripheral blood B-cell count of the patient was at nadir, and the lesion regressed slowly but spontaneously after recovery of the B-cell count. To our knowledge, although the pathologic diagnosis of Kikuchi-Fujimoto disease was unavailable, this is the first report of Kikuchi-Fujimoto disease with clinical diagnosis as a possible adverse effect of rituximab.
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KEYWORD
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B-cell, Kikuchi-Fujimoto disease, Nephrotic syndrome, Rituximab
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